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Creatine Monohydrate

Also known as creatine

The most thoroughly validated sports supplement in existence, and one of the cheapest.

Evidence
Very strong
Typical cost
$15 – $30
Permanence
Ongoing use
Timeline
Muscle saturation in 3–4 weeks without loading, roughly 1 week with.

$15–30 for several months of monohydrate.

How it works

Increases muscle phosphocreatine stores, allowing faster ATP regeneration during short high-intensity efforts. That supports greater training volume, which over time produces more lean mass. It also draws water into muscle cells.

How it's used

3–5g daily, any time of day, indefinitely. Loading phases are optional and only shorten the time to saturation. Monohydrate is the only form with a serious evidence base — everything else is a markup.

Trade-offs

In favour

  • Strong evidence for strength and lean mass gains
  • Extremely cheap
  • Excellent safety record over decades of study
  • Possible cognitive benefits under sleep deprivation

Against

  • Intracellular water retention adds 1–2kg on the scale
  • Some people report mild bloating initially
  • Effect is on training capacity, not a direct appearance change

Risks and side effects

Read before deciding
  • Generally very safe in healthy people
  • Discuss with a doctor if you have kidney disease
  • Mild GI upset if taken in large single doses

How good is the evidence?

Very strong
Extensive high-quality evidence and guideline support.

One of the most extensively studied supplements available, with consistent positive findings for strength and lean mass.

Sources

Sources point to guideline bodies and literature searches rather than single papers, so they stay accurate as the evidence moves.

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